P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT, and MEK/ERK signaling in breast cancer

Phosphatidylinositol 3-kinase (PI3K) promotes cancer cell survival, migration, growth, and proliferation by generating phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) in the inner leaflet of the plasma membrane. PIP(3) recruits pleckstrin homology (PH) domain-containing proteins to the membrane to...

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Detalles Bibliográficos
Publicado en:Oncogene
Main Authors: Dillon, Lloye M., Bean, Jennifer R., Yang, Wei, Shee, Kevin, Symonds, Lynn K., Balko, Justin M., McDonald, W. Hayes, Liu, Shuying, Gonzalez-Angulo, Ana M., Mills, Gordon B., Arteaga, Carlos L., Miller, Todd W.
Formato: Artigo
Idioma:Inglês
Publicado: 2014
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4387124/
https://ncbi.nlm.nih.gov/pubmed/25284585
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.328
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