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P-REX1 creates a positive feedback loop to activate growth factor receptor, PI3K/AKT, and MEK/ERK signaling in breast cancer
Phosphatidylinositol 3-kinase (PI3K) promotes cancer cell survival, migration, growth, and proliferation by generating phosphatidylinositol 3,4,5-trisphosphate (PIP(3)) in the inner leaflet of the plasma membrane. PIP(3) recruits pleckstrin homology (PH) domain-containing proteins to the membrane to...
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Publicado no: | Oncogene |
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Main Authors: | , , , , , , , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
2014
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4387124/ https://ncbi.nlm.nih.gov/pubmed/25284585 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.328 |
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