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Gene-directed enzyme prodrug therapy for localized chemotherapeutics in allograft and xenograft tumor models
Most chemotherapy regimens rely on systemic administration of drugs leading to a wide array of toxicities. Using viral-vector-mediated gene modification of muscle tissues, we have developed a method for gene-directed enzyme prodrug therapy that allows for localized drug administration. An inactive p...
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| Publicado no: | Cancer Gene Ther |
|---|---|
| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4387004/ https://ncbi.nlm.nih.gov/pubmed/25236494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cgt.2014.47 |
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