A Divergent Role of the SIRT1-TopBP1 Axis in Regulating Metabolic Checkpoint and DNA Damage Checkpoint

DNA replication is executed only when cells have sufficient metabolic resources and undamaged DNA. Nutrient limitation and DNA damage cause a metabolic checkpoint and DNA damage checkpoint, respectively. Although SIRT1 activity is regulated by metabolic stress and DNA damage, its function in these s...

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Gepubliceerd in:Mol Cell
Hoofdauteurs: Liu, Tongzheng, Lin, Yi-hui, Leng, Wenchuan, Jung, Sung Yun, Zhang, Haoxing, Deng, Min, Evans, Debra, Li, Yunhui, Luo, Kuntian, Qin, Bo, Qin, Jun, Yuan, Jian, Lou, Zhenkun
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386886/
https://ncbi.nlm.nih.gov/pubmed/25454945
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2014.10.007
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