Combination Metronomic Oral Topotecan and Pazopanib: A Pharmacokinetic Study in Cancer Patients with Gynecological Cancer

BACKGROUND: Combination metronomic topotecan plus pazopanib is active against preclinical models of gynecologic cancer. Both agents are substrates for ATP-binding cassette family transporters so there is an increased likelihood for pharmacokinetic (PK) drug drug interactions. PATIENTS AND METHODS: P...

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Bibliografske podrobnosti
izdano v:Anticancer Res
Main Authors: Turner, David C., Tillmanns, Todd D., Harstead, K. Elaine, Throm, Stacy L., Stewart, Clinton F.
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386652/
https://ncbi.nlm.nih.gov/pubmed/24023315
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