Metronomic Oral Topotecan with Pazopanib Is an Active Antiangiogenic Regimen in Mouse Models of Aggressive Pediatric Solid Tumor

PURPOSE: Low dose metronomic (LDM) chemotherapy, combined with VEGF signaling pathway inhibitors, is a highly effective strategy to coordinately inhibit angiogenesis and tumor growth in many adult preclinical cancer models. We have tested the efficacies of daily oral LDM topotecan alone and in combi...

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Main Authors: Kumar, Sushil, Mokhtari, Reza Bayat, Sheikh, Reihaneh, Wu, Bing, Zhang, Libo, Xu, Ping, Man, Shan, Oliveira, Indhira Dias, Yeger, Herman, Kerbel, Robert S., Baruchel, Sylvain
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3687796/
https://ncbi.nlm.nih.gov/pubmed/21788355
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0078
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