The CDX1–microRNA-215 axis regulates colorectal cancer stem cell differentiation

The transcription factor caudal-type homeobox 1 (CDX1) is a key regulator of differentiation in the normal colon and in colorectal cancer (CRC). CDX1 activates the expression of enterocyte genes, but it is not clear how the concomitant silencing of stem cell genes is achieved. MicroRNAs (miRNAs) are...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Jones, Matthew F., Hara, Toshifumi, Francis, Princy, Li, Xiao Ling, Bilke, Sven, Zhu, Yuelin, Pineda, Marbin, Subramanian, Murugan, Bodmer, Walter F., Lal, Ashish
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2015
Gaiak:
PNAS Plus
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386393/
https://ncbi.nlm.nih.gov/pubmed/25775580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503370112
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