The CDX1–microRNA-215 axis regulates colorectal cancer stem cell differentiation

The transcription factor caudal-type homeobox 1 (CDX1) is a key regulator of differentiation in the normal colon and in colorectal cancer (CRC). CDX1 activates the expression of enterocyte genes, but it is not clear how the concomitant silencing of stem cell genes is achieved. MicroRNAs (miRNAs) are...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Jones, Matthew F., Hara, Toshifumi, Francis, Princy, Li, Xiao Ling, Bilke, Sven, Zhu, Yuelin, Pineda, Marbin, Subramanian, Murugan, Bodmer, Walter F., Lal, Ashish
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386393/
https://ncbi.nlm.nih.gov/pubmed/25775580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1503370112
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