A Virtual Screen Discovers Novel, Fragment-Sized Inhibitors of Mycobacterium tuberculosis InhA

Isoniazid (INH) is usually administered to treat latent Mycobacterium tuberculosis (Mtb) infections, and is used in combination therapy to treat active tuberculosis disease (TB). Unfortunately, resistance to this drug is hampering its clinical effectiveness. INH is a prodrug that must be activated b...

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Bibliographische Detailangaben
Veröffentlicht in:J Chem Inf Model
Hauptverfasser: Perryman, Alexander L., Yu, Weixuan, Wang, Xin, Ekins, Sean, Forli, Stefano, Li, Shao-Gang, Freundlich, Joel S., Tonge, Peter J., Olson, Arthur J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4386068/
https://ncbi.nlm.nih.gov/pubmed/25636146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ci500672v
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