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Dimer monomer transition and dimer re-formation play important role for ATM cellular function during DNA repair
The ATM protein kinase, is a serine/threonine protein kinase that is recruited and activated by DNA double-strand breaks, mediates responses to ionizing radiation in mammalian cells. Here we show that ATM is held inactive in unirradiated cells as a dimer and phosphorylates the opposite strand of the...
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| Publicado no: | Biochem Biophys Res Commun |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4386021/ https://ncbi.nlm.nih.gov/pubmed/25240135 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2014.09.038 |
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