Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6

Although numerous pathogenic changes within the mitochondrial respiratory chain (RC) have been associated with an elevated occurrence of apoptosis within the affected tissues, the mechanistic insight into how mitochondrial dysfunction initiates apoptotic cell death is still unknown. In this study, w...

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Detalles Bibliográficos
Publicado en:Cell Death Dis
Autores principales: Schüll, S, Günther, S D, Brodesser, S, Seeger, J M, Tosetti, B, Wiegmann, K, Pongratz, C, Diaz, F, Witt, A, Andree, M, Brinkmann, K, Krönke, M, Wiesner, R J, Kashkar, H
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2015
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Original Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385940/
https://ncbi.nlm.nih.gov/pubmed/25766330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.62
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