Bax deficiency extends the survival of Ku70 knockout mice that develop lung and heart diseases

Ku70 (Lupus Ku autoantigen p70) is essential in nonhomologous end joining DNA double-strand break repair, and ku70(−/−) mice age prematurely because of increased genomic instability and DNA damage responses. Previously, we found that Ku70 also inhibits Bax, a key mediator of apoptosis. We hypothesiz...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Dis
Egile Nagusiak: Ngo, J, Matsuyama, M, Kim, C, Poventud-Fuentes, I, Bates, A, Siedlak, S L, Lee, H-g, Doughman, Y Q, Watanabe, M, Liner, A, Hoit, B, Voelkel, N, Gerson, S, Hasty, P, Matsuyama, S
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2015
Gaiak:
Original Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385910/
https://ncbi.nlm.nih.gov/pubmed/25811803
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2015.11
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