The anti-leukemic activity of sodium dichloroacetate in p53(mutated/null) cells is mediated by a p53-independent ILF3/p21 pathway

B-chronic lymphocytic leukemia (B-CLL) patients harboring p53 mutations are invariably refractory to therapies based on purine analogues and have limited treatment options and poor survival. Having recently demonstrated that the mitochondria-targeting small molecule sodium dichloroacetate (DCA) exhi...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Agnoletto, Chiara, Brunelli, Laura, Melloni, Elisabetta, Pastorelli, Roberta, Casciano, Fabio, Rimondi, Erika, Rigolin, Gian Matteo, Cuneo, Antonio, Secchiero, Paola, Zauli, Giorgio
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385858/
https://ncbi.nlm.nih.gov/pubmed/25544776
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