Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer

Fibroblast growth factor receptor 2 (FGFR2)-targeted therapy has attracted considerable attention as novel anticancer agents in gastric cancer (GC). However, intrinsic or acquired drug resistance has emerged as a major challenge to their clinical use. In this study, we demonstrated that several rece...

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Vydáno v:Oncotarget
Hlavní autoři: Chang, Jinjia, Wang, Shanshan, Zhang, Zhe, Liu, Xinyang, Wu, Zheng, Geng, Ruixuan, Ge, Xiaoxiao, Dai, Congqi, Liu, Rujiao, Zhang, Qunling, Li, Wenhua, Li, Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: Impact Journals LLC 2014
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Research Paper
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385832/
https://ncbi.nlm.nih.gov/pubmed/25576915
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