Validated LC-MS/MS method for the determination of 3-Hydroxflavone and its glucuronide in blood and bioequivalent buffers: Application to pharmacokinetic, absorption, and metabolism studies

The purpose of this study is to develop an UPLC-MS/MS method to quantify 3-hydroxy-flavone (3-HF) and its metabolite, 3-hydroxyflavone-glucuronide (3-HFG) from biological samples. A Waters BEH C(8) column was used with acetonitrile/0.1 % formic acid in water as mobile phases. The mass analysis was p...

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Udgivet i:J Pharm Biomed Anal
Main Authors: Xu, Beibei, Yang, Guanyi, Ge, Shufan, Yin, Taijun, Hu, Ming, Gao, Song
Format: Artigo
Sprog:Inglês
Udgivet: 2013
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4385390/
https://ncbi.nlm.nih.gov/pubmed/23973631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpba.2013.07.030
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