Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism

BCL-2 is a negative regulator of apoptosis implicated in homeostatic and pathologic cell survival. The canonical anti-apoptotic mechanism involves entrapment of activated BAX by a groove on BCL-2, preventing BAX homo-oligomerization and mitochondrial membrane poration. The BCL-2 BH4 domain also conf...

詳細記述

保存先:
書誌詳細
出版年:Mol Cell
主要な著者: Barclay, Lauren A., Wales, Thomas E., Garner, Thomas P., Wachter, Franziska, Lee, Susan, Guerra, Rachel M., Stewart, Michelle L., Braun, Craig R., Bird, Gregory H., Gavathiotis, Evripidis, Engen, John R., Walensky, Loren D.
フォーマット: Artigo
言語:Inglês
出版事項: 2015
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384643/
https://ncbi.nlm.nih.gov/pubmed/25684204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.014
タグ: タグ追加
タグなし, このレコードへの初めてのタグを付けませんか!

類似資料