Inhibition of Pro-Apoptotic BAX by a Noncanonical Interaction Mechanism

BCL-2 is a negative regulator of apoptosis implicated in homeostatic and pathologic cell survival. The canonical anti-apoptotic mechanism involves entrapment of activated BAX by a groove on BCL-2, preventing BAX homo-oligomerization and mitochondrial membrane poration. The BCL-2 BH4 domain also conf...

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Pubblicato in:Mol Cell
Autori principali: Barclay, Lauren A., Wales, Thomas E., Garner, Thomas P., Wachter, Franziska, Lee, Susan, Guerra, Rachel M., Stewart, Michelle L., Braun, Craig R., Bird, Gregory H., Gavathiotis, Evripidis, Engen, John R., Walensky, Loren D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384643/
https://ncbi.nlm.nih.gov/pubmed/25684204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2015.01.014
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