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Autoinhibition of Bruton's tyrosine kinase (Btk) and activation by soluble inositol hexakisphosphate

Bruton's tyrosine kinase (Btk), a Tec-family tyrosine kinase, is essential for B-cell function. We present crystallographic and biochemical analyses of Btk, which together reveal molecular details of its autoinhibition and activation. Autoinhibited Btk adopts a compact conformation like that of...

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Библиографические подробности
Опубликовано в: :eLife
Главные авторы: Wang, Qi, Vogan, Erik M, Nocka, Laura M, Rosen, Connor E, Zorn, Julie A, Harrison, Stephen C, Kuriyan, John
Формат: Artigo
Язык:Inglês
Опубликовано: eLife Sciences Publications, Ltd 2015
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4384635/
https://ncbi.nlm.nih.gov/pubmed/25699547
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.06074
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