Immunogenicity, Protective Efficacy, and Non-Replicative Status of the HSV-2 Vaccine Candidate HSV529 in Mice and Guinea Pigs

HSV-2 vaccine is needed to prevent genital disease, latent infection, and virus transmission. A replication-deficient mutant virus (dl5-29) has demonstrated promising efficacy in animal models of genital herpes. However, the immunogenicity, protective efficacy, and non-replicative status of the high...

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Udgivet i:PLoS One
Main Authors: Bernard, Marie-Clotilde, Barban, Véronique, Pradezynski, Fabrine, de Montfort, Aymeric, Ryall, Robert, Caillet, Catherine, Londono-Hayes, Patricia
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383384/
https://ncbi.nlm.nih.gov/pubmed/25837802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121518
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