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Structural basis for ligand and innate immunity factor uptake by the trypanosome haptoglobin-haemoglobin receptor

The haptoglobin-haemoglobin receptor (HpHbR) of African trypanosomes allows acquisition of haem and provides an uptake route for trypanolytic factor-1, a mediator of innate immunity against trypanosome infection. In this study, we report the structure of Trypanosoma brucei HpHbR in complex with huma...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Lane-Serff, Harriet, MacGregor, Paula, Lowe, Edward D, Carrington, Mark, Higgins, Matthew K
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4383175/
https://ncbi.nlm.nih.gov/pubmed/25497229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.05553
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