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Tyrosyl radical in haemoglobin and haptoglobin-haemoglobin complex: how does haptoglobin make haemoglobin less toxic?

One of the difficulties in creating a blood substitute on the basis of human haemoglobin (Hb) is the toxic nature of Hb when it is outside the safe environment of the red blood cells. The plasma protein haptoglobin (Hp) takes care of the Hb physiologically leaked into the plasma – it binds Hb and ma...

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Detalhes bibliográficos
Publicado no:J Biomed Res
Main Authors: Svistunenko, Dimitri A., Manole, Andreea
Formato: Artigo
Idioma:Inglês
Publicado em: Editorial Department of Journal of Biomedical Research 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7386409/
https://ncbi.nlm.nih.gov/pubmed/32475850
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7555/JBR.33.20180084
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