Structure of the trypanosome haptoglobin–hemoglobin receptor and implications for nutrient uptake and innate immunity

African trypanosomes are protected by a densely packed surface monolayer of variant surface glycoprotein (VSG). A haptoglobin–hemoglobin receptor (HpHbR) within this VSG coat mediates heme acquisition. HpHbR is also exploited by the human host to mediate endocytosis of trypanolytic factor (TLF)1 fro...

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Bibliografske podrobnosti
Main Authors: Higgins, Matthew K., Tkachenko, Olga, Brown, Alan, Reed, Jenny, Raper, Jayne, Carrington, Mark
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2013
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3562850/
https://ncbi.nlm.nih.gov/pubmed/23319650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214943110
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