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Structure of the trypanosome haptoglobin–hemoglobin receptor and implications for nutrient uptake and innate immunity
African trypanosomes are protected by a densely packed surface monolayer of variant surface glycoprotein (VSG). A haptoglobin–hemoglobin receptor (HpHbR) within this VSG coat mediates heme acquisition. HpHbR is also exploited by the human host to mediate endocytosis of trypanolytic factor (TLF)1 fro...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3562850/ https://ncbi.nlm.nih.gov/pubmed/23319650 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1214943110 |
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