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Translational diffusion of hydration water correlates with functional motions in folded and intrinsically disordered proteins

Hydration water is the natural matrix of biological macromolecules and is essential for their activity in cells. The coupling between water and protein dynamics has been intensively studied, yet it remains controversial. Here we combine protein perdeuteration, neutron scattering and molecular dynami...

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Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Schirò, Giorgio, Fichou, Yann, Gallat, Francois-Xavier, Wood, Kathleen, Gabel, Frank, Moulin, Martine, Härtlein, Michael, Heyden, Matthias, Colletier, Jacques-Philippe, Orecchini, Andrea, Paciaroni, Alessandro, Wuttke, Joachim, Tobias, Douglas J., Weik, Martin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382692/
https://ncbi.nlm.nih.gov/pubmed/25774711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7490
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