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VEGF-C/VEGFR-3 Signaling Regulates Chemokine Gradients and Lymphocyte Migration from Tissues to Lymphatics

BACKGROUND: Circulation of leukocytes via blood, tissue and lymph is integral to adaptive immunity. Afferent lymphatics form CCL21 gradients to guide DC and T cells to lymphatics and then to draining lymph nodes (dLN). VEGF-C and VEGFR-3 are the major lymphatic growth factor and receptor. We hypothe...

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Publicado en:Transplantation
Autores principales: Iwami, Daiki, Brinkman, C. Colin, Bromberg, Jonathan S.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382428/
https://ncbi.nlm.nih.gov/pubmed/25606800
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0000000000000561
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