Treg engage lymphotoxin beta receptor for afferent lymphatic transendothelial migration

Regulatory T cells (Tregs) are essential to suppress unwanted immunity or inflammation. After islet allo-transplant Tregs must migrate from blood to allograft, then via afferent lymphatics to draining LN to protect allografts. Here we show that Tregs but not non-Treg T cells use lymphotoxin (LT) dur...

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Publicado en:Nat Commun
Autores principales: Brinkman, C. Colin, Iwami, Daiki, Hritzo, Molly K., Xiong, Yanbao, Ahmad, Sarwat, Simon, Thomas, Hippen, Keli L., Blazar, Bruce R., Bromberg, Jonathan S.
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4919545/
https://ncbi.nlm.nih.gov/pubmed/27323847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12021
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