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Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration

Alternative splicing of nucleoredoxin-like 1 (Nxnl1) results in 2 isoforms of the rod-derived cone viability factor. The truncated form (RdCVF) is a thioredoxin-like protein secreted by rods that promotes cone survival, while the full-length isoform (RdCVFL), which contains a thioredoxin fold, is in...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Clin Invest
Prif Awduron: Byrne, Leah C., Dalkara, Deniz, Luna, Gabriel, Fisher, Steven K., Clérin, Emmanuelle, Sahel, Jose-Alain, Léveillard, Thierry, Flannery, John G.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Clinical Investigation 2014
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382269/
https://ncbi.nlm.nih.gov/pubmed/25415434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI65654
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