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Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins

The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous systems. Specifically, the major insertion region (MIR) on the HBcAg protein allows the insertion of foreign sequences, which are then expos...

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書目詳細資料
發表在:PLoS One
Main Authors: Peyret, Hadrien, Gehin, Annick, Thuenemann, Eva C., Blond, Donatienne, El Turabi, Aadil, Beales, Lucy, Clarke, Dean, Gilbert, Robert J. C., Fry, Elizabeth E., Stuart, David I., Holmes, Kris, Stonehouse, Nicola J., Whelan, Mike, Rosenberg, William, Lomonossoff, George P., Rowlands, David J.
格式: Artigo
語言:Inglês
出版: Public Library of Science 2015
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382129/
https://ncbi.nlm.nih.gov/pubmed/25830365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120751
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