Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins

The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous systems. Specifically, the major insertion region (MIR) on the HBcAg protein allows the insertion of foreign sequences, which are then expos...

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Udgivet i:PLoS One
Main Authors: Peyret, Hadrien, Gehin, Annick, Thuenemann, Eva C., Blond, Donatienne, El Turabi, Aadil, Beales, Lucy, Clarke, Dean, Gilbert, Robert J. C., Fry, Elizabeth E., Stuart, David I., Holmes, Kris, Stonehouse, Nicola J., Whelan, Mike, Rosenberg, William, Lomonossoff, George P., Rowlands, David J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382129/
https://ncbi.nlm.nih.gov/pubmed/25830365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120751
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