Tandem Fusion of Hepatitis B Core Antigen Allows Assembly of Virus-Like Particles in Bacteria and Plants with Enhanced Capacity to Accommodate Foreign Proteins

The core protein of the hepatitis B virus, HBcAg, assembles into highly immunogenic virus-like particles (HBc VLPs) when expressed in a variety of heterologous systems. Specifically, the major insertion region (MIR) on the HBcAg protein allows the insertion of foreign sequences, which are then expos...

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Publicat a:PLoS One
Autors principals: Peyret, Hadrien, Gehin, Annick, Thuenemann, Eva C., Blond, Donatienne, El Turabi, Aadil, Beales, Lucy, Clarke, Dean, Gilbert, Robert J. C., Fry, Elizabeth E., Stuart, David I., Holmes, Kris, Stonehouse, Nicola J., Whelan, Mike, Rosenberg, William, Lomonossoff, George P., Rowlands, David J.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4382129/
https://ncbi.nlm.nih.gov/pubmed/25830365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120751
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