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Identification of human presequence protease (hPreP) agonists for the treatment of Alzheimer’s disease
Amyloid-β (Aβ), a neurotoxic peptide, is linked to the onset of Alzheimer’s disease (AD). Increased Aβ content within neuronal cell mitochondria is a pathological feature in both human and mouse models with AD. This accumulation of Aβ within the mitochondrial landscape perpetuates increased free rad...
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| 發表在: | Eur J Med Chem |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2014
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4381964/ https://ncbi.nlm.nih.gov/pubmed/24602793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ejmech.2014.02.046 |
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