Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

The mechanisms underlying preferential atrophy of the striatum in Huntington's disease (HD) are unknown. One hypothesis is that a set of gene products preferentially expressed in the striatum could determine the particular vulnerability of this brain region to mutant huntingtin (mHtt). Here, we...

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Bibliografski detalji
Izdano u:Hum Mol Genet
Glavni autori: Francelle, Laetitia, Galvan, Laurie, Gaillard, Marie-Claude, Guillermier, Martine, Houitte, Diane, Bonvento, Gilles, Petit, Fanny, Jan, Caroline, Dufour, Noëlle, Hantraye, Philippe, Elalouf, Jean-Marc, De Chaldée, Michel, Déglon, Nicole, Brouillet, Emmanuel
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
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Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381754/
https://ncbi.nlm.nih.gov/pubmed/25398949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu571
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