Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

The mechanisms underlying preferential atrophy of the striatum in Huntington's disease (HD) are unknown. One hypothesis is that a set of gene products preferentially expressed in the striatum could determine the particular vulnerability of this brain region to mutant huntingtin (mHtt). Here, we...

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Publié dans:Hum Mol Genet
Auteurs principaux: Francelle, Laetitia, Galvan, Laurie, Gaillard, Marie-Claude, Guillermier, Martine, Houitte, Diane, Bonvento, Gilles, Petit, Fanny, Jan, Caroline, Dufour, Noëlle, Hantraye, Philippe, Elalouf, Jean-Marc, De Chaldée, Michel, Déglon, Nicole, Brouillet, Emmanuel
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2015
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381754/
https://ncbi.nlm.nih.gov/pubmed/25398949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu571
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