Loss of the thyroid hormone-binding protein Crym renders striatal neurons more vulnerable to mutant huntingtin in Huntington's disease

The mechanisms underlying preferential atrophy of the striatum in Huntington's disease (HD) are unknown. One hypothesis is that a set of gene products preferentially expressed in the striatum could determine the particular vulnerability of this brain region to mutant huntingtin (mHtt). Here, we...

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Bibliografske podrobnosti
izdano v:Hum Mol Genet
Main Authors: Francelle, Laetitia, Galvan, Laurie, Gaillard, Marie-Claude, Guillermier, Martine, Houitte, Diane, Bonvento, Gilles, Petit, Fanny, Jan, Caroline, Dufour, Noëlle, Hantraye, Philippe, Elalouf, Jean-Marc, De Chaldée, Michel, Déglon, Nicole, Brouillet, Emmanuel
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2015
Teme:
Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381754/
https://ncbi.nlm.nih.gov/pubmed/25398949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddu571
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