Syringaresinol protects against hypoxia/reoxygenation-induced cardiomyocytes injury and death by destabilization of HIF-1α in a FOXO3-dependent mechanism

Hypoxia-inducible factor 1 (HIF-1) is a master regulator of hypoxic response and has been a prime therapeutic target for ischemia/reperfusion (I/R)-derived myocardial dysfunction and tissue damage. There is also increasing evidence that HIF-1 plays a central role in regulating aging, both through in...

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Veröffentlicht in:Oncotarget
Hauptverfasser: Cho, Siyoung, Cho, Miook, Kim, Juewon, Kaeberlein, Matt, Lee, Sang Jun, Suh, Yousin
Format: Artigo
Sprache:Inglês
Veröffentlicht: Impact Journals LLC 2014
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Priority Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4381577/
https://ncbi.nlm.nih.gov/pubmed/25415049
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