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Detergent-solubilized Patched Purified from Sf9 Cells Fails to Interact Strongly With Cognate Hedgehog or Ihog Homologs

Patched (Ptc) is a twelve-pass transmembrane protein that functions as a receptor for the Hedgehog (Hh) family of morphogens. In addition to Ptc, several accessory proteins including the CDO/Ihog family of co-receptors are necessary for proper Hh signaling. Structures of Hh proteins bound to members...

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Bibliografski detalji
Izdano u:Protein Expr Purif
Glavni autori: Cleveland, Thomas E., McCabe, Jacqueline M., Leahy, Daniel J.
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380871/
https://ncbi.nlm.nih.gov/pubmed/25261717
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.pep.2014.09.012
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