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Structure of a heparin-dependent complex of Hedgehog and Ihog

Hedgehog (Hh) signaling molecules mediate key tissue-patterning events during animal development, and inappropriate activation of Hh signaling in adults has been associated with human cancers. Recently, a conserved family of type I integral membrane proteins required for normal response to the Hh si...

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Autors principals: McLellan, Jason S., Yao, Shenqin, Zheng, Xiaoyan, Geisbrecht, Brian V., Ghirlando, Rodolfo, Beachy, Philip A., Leahy, Daniel J.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2006
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1859911/
https://ncbi.nlm.nih.gov/pubmed/17077139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0606738103
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