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Activated Mutant p110α Causes Endometrial Carcinoma in the Setting of Biallelic Pten Deletion
PTEN and PIK3CA mutations occur with high frequency in uterine endometrioid carcinoma (UEC). Although PTEN mutations are present in complex atypical hyperplasia and carcinoma, PIK3CA mutations are restricted to carcinoma. We generated mouse models harboring Pten loss and/or activated Pik3ca in the e...
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| 出版年: | Am J Pathol |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Society for Investigative Pathology
2015
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4380850/ https://ncbi.nlm.nih.gov/pubmed/25698082 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ajpath.2014.12.019 |
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