The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten

Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the uterus. We previously showed that Pten deletion in the mouse uterus using a Pgr-Cre driver (Pten(f/f)Pgr(Cre/+)) results in rapid development of endometrial carcinoma (EMC) with full penetration. We al...

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Enregistré dans:
Détails bibliographiques
Publié dans:PLoS Genet
Auteurs principaux: Liang, Xiaohuan, Daikoku, Takiko, Terakawa, Jumpei, Ogawa, Yuya, Joshi, Ayesha R., Ellenson, Lora H., Sun, Xiaofei, Dey, Sudhansu K.
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126871/
https://ncbi.nlm.nih.gov/pubmed/30142194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007630
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