The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten

Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the uterus. We previously showed that Pten deletion in the mouse uterus using a Pgr-Cre driver (Pten(f/f)Pgr(Cre/+)) results in rapid development of endometrial carcinoma (EMC) with full penetration. We al...

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Bibliografski detalji
Izdano u:PLoS Genet
Glavni autori: Liang, Xiaohuan, Daikoku, Takiko, Terakawa, Jumpei, Ogawa, Yuya, Joshi, Ayesha R., Ellenson, Lora H., Sun, Xiaofei, Dey, Sudhansu K.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2018
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126871/
https://ncbi.nlm.nih.gov/pubmed/30142194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007630
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