The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten

Mutation of the tumor suppressor Pten often leads to tumorigenesis in various organs including the uterus. We previously showed that Pten deletion in the mouse uterus using a Pgr-Cre driver (Pten(f/f)Pgr(Cre/+)) results in rapid development of endometrial carcinoma (EMC) with full penetration. We al...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Liang, Xiaohuan, Daikoku, Takiko, Terakawa, Jumpei, Ogawa, Yuya, Joshi, Ayesha R., Ellenson, Lora H., Sun, Xiaofei, Dey, Sudhansu K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6126871/
https://ncbi.nlm.nih.gov/pubmed/30142194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007630
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