Tyrosine phosphatase PTPα regulates focal adhesion remodeling through Rac1 activation

We characterized the role of protein tyrosine phosphatase (PTP)-α in focal adhesion (FA) formation and remodeling using wild-type and PTPα-deficient (PTPα(−/−)) cells. Compared with wild-type cells, spreading PTPα(−/−) fibroblasts displayed fewer leading edges and formed elongated α-actinin-enriched...

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Bibliographic Details
Published in:Am J Physiol Cell Physiol
Main Authors: Herrera Abreu, Maria Teresa, Castellanos Penton, Patricia, Kwok, Vivian, Vachon, Eric, Shalloway, David, Vidali, Luis, Lee, Wilson, McCulloch, Christopher A., Downey, Gregory P.
Format: Artigo
Language:Inglês
Published: American Physiological Society 2008
Subjects:
Extracellular Matrix, Cell Interactions
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4380481/
https://ncbi.nlm.nih.gov/pubmed/18216165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00359.2007
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