Protein-tyrosine Phosphatase-α and Src Functionally Link Focal Adhesions to the Endoplasmic Reticulum to Mediate Interleukin-1-induced Ca(2+) Signaling

Calcium (Ca(2+)) signaling by the pro-inflammatory cytokine interleukin-1 (IL-1) is dependent on focal adhesions, which contain diverse structural and signaling proteins including protein phosphatases. We examined here the role of protein-tyrosine phosphatase (PTP) α in regulating IL-1-induced Ca(2+...

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Bibliographic Details
Main Authors: Wang, Qin, Rajshankar, Dhaarmini, Branch, Donald R., Siminovitch, Katherine A., Abreu, Maria Teresa Herrera, Downey, Gregory P., McCulloch, Christopher A.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Mechanisms of Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742840/
https://ncbi.nlm.nih.gov/pubmed/19497848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M808828200
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