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Somatic cancer mutations in the MLL3-SET domain alter the catalytic properties of the enzyme
BACKGROUND: Somatic mutations in epigenetic enzymes are frequently found in cancer tissues. The MLL3 H3K4-specific protein lysine monomethyltransferase is an important epigenetic enzyme, and it is among the most recurrently mutated enzymes in cancers. MLL3 mainly introduces H3K4me1 at enhancers. RES...
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| Published in: | Clin Epigenetics |
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| Main Authors: | , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
BioMed Central
2015
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4379744/ https://ncbi.nlm.nih.gov/pubmed/25829971 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13148-015-0075-3 |
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