Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by K(Ca)3.1 K(+) channels

BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a common and invariably lethal interstitial lung disease with poorly effective therapy. Blockade of the K(+) channel K(Ca)3.1 reduces constitutive α-SMA and Smad2/3 nuclear translocation in IPF-derived human lung myofibroblasts (HLMFs), and inhibits...

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Enregistré dans:
Détails bibliographiques
Publié dans:Fibrogenesis Tissue Repair
Auteurs principaux: Roach, Katy M, Feghali-Bostwick, Carol, Wulff, Heike, Amrani, Yassine, Bradding, Peter
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379608/
https://ncbi.nlm.nih.gov/pubmed/25829947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13069-015-0022-0
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