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Human lung myofibroblast TGFβ1-dependent Smad2/3 signalling is Ca(2+)-dependent and regulated by K(Ca)3.1 K(+) channels
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a common and invariably lethal interstitial lung disease with poorly effective therapy. Blockade of the K(+) channel K(Ca)3.1 reduces constitutive α-SMA and Smad2/3 nuclear translocation in IPF-derived human lung myofibroblasts (HLMFs), and inhibits...
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| Publicado no: | Fibrogenesis Tissue Repair |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BioMed Central
2015
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4379608/ https://ncbi.nlm.nih.gov/pubmed/25829947 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13069-015-0022-0 |
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