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Increased constitutive αSMA and Smad2/3 expression in idiopathic pulmonary fibrosis myofibroblasts is K(Ca)3.1-dependent
BACKGROUND: Idiopathic pulmonary fibrosis is a common and invariably fatal disease with limited therapeutic options. Ca(2+)-activated K(Ca)3.1 potassium channels play a key role in promoting TGFβ1 and bFGF-dependent profibrotic responses in human lung myofibroblasts (HLMFs). We hypothesised that K(C...
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| Pubblicato in: | Respir Res |
|---|---|
| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BioMed Central
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4263015/ https://ncbi.nlm.nih.gov/pubmed/25476248 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-014-0155-5 |
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