ATRX Directs Binding of PRC2 to Xist RNA and Polycomb Targets

X chromosome inactivation (XCI) depends on the long noncoding RNA Xist and its recruitment of Polycomb Repressive Complex 2 (PRC2). PRC2 is also targeted to other sites throughout the genome to effect transcriptional repression. Using XCI as a model, we apply an unbiased proteomics approach to isola...

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Veröffentlicht in:Cell
Hauptverfasser: Sarma, Kavitha, Cifuentes-Rojas, Catherine, Ergun, Ayla, del Rosario, Amanda, Jeon, Yesu, White, Forest, Sadreyev, Ruslan, Lee, Jeannie T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4379047/
https://ncbi.nlm.nih.gov/pubmed/25417162
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2014.10.019
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