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Proline dehydrogenase 2 (PRODH2) is a hydroxyproline dehydrogenase (HYPDH) and molecular target for treating primary hyperoxaluria

The primary hyperoxalurias (PH), types 1–3, are disorders of glyoxylate metabolism that result in increased oxalate production and calcium oxalate stone formation. The breakdown of trans-4-hydroxy-L-proline (Hyp) from endogenous and dietary sources of collagen makes a significant contribution to the...

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Detalles Bibliográficos
Publicado en:Biochem J
Main Authors: Summitt, Candice B., Johnson, Lynnette C., Jönsson, Thomas J., Parsonage, Derek, Holmes, Ross P., Lowther, W. Todd
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377293/
https://ncbi.nlm.nih.gov/pubmed/25697095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20141159
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