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Structural and Biochemical Studies of Human 4-hydroxy-2-oxoglutarate Aldolase: Implications for Hydroxyproline Metabolism in Primary Hyperoxaluria

BACKGROUND: 4-hydroxy-2-oxoglutarate (HOG) aldolase is a unique enzyme in the hydroxyproline degradation pathway catalyzing the cleavage of HOG to pyruvate and glyoxylate. Mutations in this enzyme are believed to be associated with the excessive production of oxalate in primary hyperoxaluria type 3...

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Detalhes bibliográficos
Main Authors: Riedel, Travis J., Johnson, Lynnette C., Knight, John, Hantgan, Roy R., Holmes, Ross P., Lowther, W. Todd
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3188589/
https://ncbi.nlm.nih.gov/pubmed/21998747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0026021
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