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Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition

Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loo...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Cell
Hauptverfasser: Doncic, Andreas, Atay, Oguzhan, Valk, Ervin, Grande, Alicia, Bush, Alan, Vasen, Gustavo, Colman-Lerner, Alejandro, Loog, Mart, Skotheim, Jan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377233/
https://ncbi.nlm.nih.gov/pubmed/25768911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.032
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