Compartmentalization of a bistable switch enables memory to cross a feedback-driven transition

Cells make accurate decisions in the face of molecular noise and environmental fluctuations by relying not only on present pathway activity, but also on their memory of past signaling dynamics. Once a decision is made, cellular transitions are often rapid and switch-like due to positive feedback loo...

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Bibliografiske detaljer
Udgivet i:Cell
Main Authors: Doncic, Andreas, Atay, Oguzhan, Valk, Ervin, Grande, Alicia, Bush, Alan, Vasen, Gustavo, Colman-Lerner, Alejandro, Loog, Mart, Skotheim, Jan M.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377233/
https://ncbi.nlm.nih.gov/pubmed/25768911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2015.02.032
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