Association of an inherited genetic variant with vincristine-related peripheral neuropathy in children with acute lymphoblastic leukemia

IMPORTANCE: With cure rates of childhood acute lymphoblastic leukemia (ALL) exceeding 85%, there is compelling need to mitigate treatment toxicities that can compromise quality of life. Peripheral neuropathy is the major dose-limiting toxicity of the microtubule inhibitor vincristine, an anticancer...

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Publicado no:JAMA
Main Authors: Diouf, Barthelemy, Crews, Kristine R., Lew, Glen, Pei, Deqing, Cheng, Cheng, Bao, Ju, Zheng, Jie J., Yang, Wenjian, Fan, Yiping, Wheeler, Heather E., Wing, Claudia, Delaney, Shannon M., Komatsu, Masaaki, Paugh, Steven W., McCorkle, Joseph Robert, Lu, Xiaomin, Winick, Naomi J., Carroll, William L., Loh, Mignon L., Hunger, Stephen P., Devidas, Meenakshi, Pui, Ching-Hon, Dolan, M. Eileen, Relling, Mary V., Evans, William E.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4377066/
https://ncbi.nlm.nih.gov/pubmed/25710658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1001/jama.2015.0894
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